As you would expect from something with a standard BIOS I had no problems running Tiny Core 9.0 from a pen drive.
Out of interest I tried out Fedora 28 Workstation and that booted and ran without any problems.
In April 2020 I tried out an 8GB RAM part. I had no problems with BionicPup64 8.0 which happily found and used the full 8GB of RAM..