As you would expect I had no problem running the latest version of Tiny Core Linux (7.0) from a 1GB pen drive or with it installed to the internal flash memory. However, as I'm using an 803.3af PoE power supply, only USB ports 1 and 2 are enabled. Ports 3 and 4 (on the front) are dead.
I had a brief look at the USB setup and tried to see if I could enable the dead ports - so far without any success. I haven't exhausted all the possibilities and may return to this if and when I have time. If you have more success than I have then please email me using the link at the bottom of the page.